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Whar are the risks?

The use of Mephedrone in high dosages leads to unpleasant side effects that are typical for other stimulants, too. These include:

•    Nausea
•    Grinding teeth
•    Compulsive desire for taking additional doses
•    Heart palpitations, racing heart
•    Increased blood pressure

Contraindications

•    Mephedrone should not be taken together with Monoamine oxidase inhibitors (MAOI), which are some types of antidepressants the physicians prescribe. Ayahuaska, too, contains MAOI such as harmine and harmalin. Taking stimulants in combination with MAOI is extremely risky.
•    After having taken Mephedrone, users should not drive vehicles or operate machines.
•    Users suffering from cardio-vascular diseases, as well as from diseases causing faints and convulsions, are exposed to higher risk.

Long-Term Risks

Some users report for problems related to vasoconstrictions, especially after having taken additional doses. Those problems include slight to severe symptoms of limbs going asleep or growing numb, headaches, dizziness, and alarming skin discoloration.

Risk of death

Risks of death related to the use of stimulants often result in cardiovascular problems, overheating, and accidents related to intoxication and multi-drug combinations. So far, at least several death cases have been related to the use of Mephedrone.

Information sources:
http://www.erowid.org/chemicals/4_methylmethcathinone/4_methylmethcathinone.shtml
http://www.springerlink.com/content/cl4g710287g76572/
http://www.emcdda.europa.eu/publications/drug-profiles/synthetic-cathinones
http://www.nfp-drugs.bg/bg/?&itype=168&info=2195